一些生物活性2-溴-5-甲氧基-N'-[4-(芳基)-1,3-噻唑-2-基]苯甲酰肼衍生物的合成
Synthesis of some bioactive 2-bromo-5-methoxy-N'-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives.
作者信息
Vijaya Raj K K, Narayana B, Ashalatha B V, Suchetha Kumari N, Sarojini B K
机构信息
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri, Mangalore 574 199, Karnataka, India.
出版信息
Eur J Med Chem. 2007 Mar;42(3):425-9. doi: 10.1016/j.ejmech.2006.09.010. Epub 2006 Oct 30.
Eight novel 2-bromo-5-methoxy-N'-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.
制备了八种新型的2-溴-5-甲氧基-N'-[4-(芳基)-1,3-噻唑-2-基]苯甲酰肼衍生物，并通过分析和光谱分析对其进行了表征。对所有化合物进行了镇痛、抗真菌和抗菌活性筛选，对其中三种化合物进行了抗增殖活性筛选。两种新合成的化合物表现出有前景的镇痛活性，一种化合物表现出体外抗增殖活性。
Zotero 插件