Komarek J, Parish G A
Arzneimittelforschung. 1975 May;25(5):737-40.
The activity of adenosine and inosine on coronary blood flow and arterial blood pressure was investigated in anaesthetized and thoracotomized dogs. The following results were obtained. 1. Individual adenosine administration caused an increase in coronary blood flow. However, this adenosine activity was significantly strengthened when the same dose of adenosine was applied simultaneously with inosine in doses of 3.2, 5.6 and 10.0 mg/kg body weight i.v. The duration of the effect of adenosine on the coronary blood flow was also potentiated by inosine. 2. The hypotensive effect resulting from 0.2 mg adenosine/kg i.v. was significantly strengthened by simultaneous inosine application (3.2, 5.6 and 10.0 mg/kg i.v.). The activities on the blood pressure of increments in the individual adenosine dosages (0.2, 0.4 and 0.6 mg/kg i.v.) were significantly potentiated by 10 mg inosine/kg body weight i.v. 3. The heart rate was not modified by 0.2 mg adenosine/kg i.v. However, the same adenosine dosage plus inosine (3.2, 5.6 and 10.0 mg/kg i.v.) applied simultaneously led to bradycardia. Increasing adenosine doses (0.2, 0.4 and 0.6 mg/kg i.v.) applied simultaneously with inosine (10.0 mg/kg body weight i.v.) led to a dose dependent retardation of the heart rate. 4. The possible reasons for the potentiation of the effect of adenosine by inosine were discussed.
在麻醉并开胸的犬身上研究了腺苷和肌苷对冠状动脉血流量及动脉血压的作用。得到了以下结果。1. 单独给予腺苷会使冠状动脉血流量增加。然而，当以3.2、5.6和10.0毫克/千克体重的剂量静脉注射肌苷并同时给予相同剂量的腺苷时，腺苷的这种作用会显著增强。肌苷还能增强腺苷对冠状动脉血流量作用的持续时间。2. 静脉注射0.2毫克/千克腺苷所产生的降压作用，因同时应用肌苷（3.2、5.6和10.0毫克/千克静脉注射）而显著增强。静脉注射10毫克/千克体重的肌苷能显著增强单独增加腺苷剂量（0.2、0.4和0.6毫克/千克静脉注射）对血压的作用。3. 静脉注射0.2毫克/千克腺苷不会改变心率。然而，同时应用相同剂量的腺苷加肌苷（3.2、5.6和10.0毫克/千克静脉注射）会导致心动过缓。静脉注射肌苷（10.0毫克/千克体重）并同时增加腺苷剂量（0.2、0.4和0.6毫克/千克静脉注射）会导致心率呈剂量依赖性减慢。4. 讨论了肌苷增强腺苷作用的可能原因。
