Sakai K, Akima M
Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):55-9. doi: 10.1007/BF00586597.
The isolated right hindlimb of the rat was perfused at a fixed flow rate through the femoral artery with heparinized blood from the carotid artery of a donor. Single injections of adenosine (1--300 microgram) induced a biphasic response, a long-lasting vasoconstriction preceded by a transient vasodilatation. Inosine (1--300 microgram) produced only vasoconstriction. After repeated administration of 300 microgram of these substances, the vasoconstriction became less prominent, and finally reverted to vasodilatation. The vasoconstrictor response to these substances (300 microgram) was also diminished or reverted to vasodilatation after pretreatment with reserpine or methysergide. From these results, it is concluded that vasoconstriction after adenosine or inosine may be mediated by 5-hydroxytryptamine released from the peripheral stores and that the intrinsic direct action of these substances on the femoral vascular bed is vasodilator.
将大鼠的离体右后肢通过股动脉以固定流速用来自供体颈动脉的肝素化血液进行灌注。单次注射腺苷（1 - 300微克）可诱发双相反应，即短暂的血管舒张之后是持久的血管收缩。肌苷（1 - 300微克）仅产生血管收缩。重复给予300微克这些物质后，血管收缩变得不那么明显，最终转变为血管舒张。在用利血平或甲基麦角新碱预处理后，对这些物质（300微克）的血管收缩反应也减弱或转变为血管舒张。从这些结果可以得出结论，腺苷或肌苷后的血管收缩可能由外周储存释放的5 - 羟色胺介导，并且这些物质对股血管床的内在直接作用是血管舒张剂。
