Juhran V W, Haase W, Götz R, Fleissig W
Arzneimittelforschung. 1975 May;25(5):771-3.
The serum levels of intravenously and orally given papaverine were determined in healthy, fasting beagles. The bioavailability of the drug was assessed in the same animals following single administration of the sustained-action preparation Panergon (papaverine-hydrochloride). Based on a one-compartment model, the time of invasion, the half-life of elimination, the volume of distribution and the absorption rate of papaverine were calcualted. A comparison of the areas under the concentration curves shows the complete bioavailability of the papaverine contained in Panergon.
在健康、禁食的比格犬中测定静脉注射和口服罂粟碱后的血清水平。在同一批动物单次给予缓释制剂潘埃贡（盐酸罂粟碱）后评估该药物的生物利用度。基于单室模型，计算罂粟碱的起效时间、消除半衰期、分布容积和吸收速率。浓度曲线下面积的比较显示了潘埃贡中所含罂粟碱的完全生物利用度。
