Ritschel W A, Hammer G V
Int J Clin Pharmacol Biopharm. 1977 May;15(5):227-8.
A retrospective pharmacokinetic analysis was done of papaverine plasma level data in man reported in the literature. Upon i.v. administration the plasma level vs time curve can best be described by an open two-compartment model, and upon p.o. administration by open-compartment model. The biological half-life of papaverine varies between 1.5 and 2.2 hours, and has a volume of distribution of approximately 15% of the body weight. Papaverine is practically completely metabolized and underlies the first-pass effect upon p.o. administration.
对文献报道的人体中罂粟碱血浆水平数据进行了回顾性药代动力学分析。静脉注射给药后，血浆水平-时间曲线最适合用开放二室模型描述，口服给药后用开放房室模型描述。罂粟碱的生物半衰期在1.5至2.2小时之间，分布容积约为体重的15%。罂粟碱几乎完全代谢，口服给药时存在首过效应。
