Frohberg H
Arzneimittelforschung. 1975 Jul;25(7a):1101-10.
The different steps of the toxicological testing of new drugs are shortly described. Furthermore it is discussed that only 60-70% of the drug induced adverse reactions in man can be predicted by the experimental methods being available at present. Special problems exist in evaluating the results of reproductive-toxicological, carcinogenicity and mutagenicity tests. These problems are illustrated by some experimental and clinical examples.
本文简要描述了新药毒理学测试的不同步骤。此外，还讨论了目前可用的实验方法仅能预测60%-70%的药物在人体中引起的不良反应。在评估生殖毒理学、致癌性和致突变性测试结果时存在特殊问题。文中通过一些实验和临床实例对这些问题进行了说明。
