von Hattingberg H M
Arzneimittelforschung. 1975 Jul;25(7a):1126-33.
Pharmacokinetics have become one indispensable tool in drug evaluation, clinical pharmacology and diagnostics. Therefore the basic principles of pharmacokinetics are outlined and pertinent definitions are given. Some scientific terms in this field are explained in order to facilitate interdisciplinary communication. The theoretical background of some practicable algorithms for obtaining pharmacokinetical parameters is described with the attempt of relying solely on the understanding usually induced by basic courses in biology, medicine and chemistry. It is demonstrated that the evaluation of pharmacokinetical analyses may only be interpreted in a context of any or all of these disciplines. Without this context pharmacokinetical results may remain mere mathematical descriptions of unknown mechanisms.
药代动力学已成为药物评价、临床药理学和诊断学中不可或缺的工具。因此，本文概述了药代动力学的基本原理并给出了相关定义。对该领域的一些科学术语进行了解释，以促进跨学科交流。描述了一些用于获取药代动力学参数的实用算法的理论背景，试图仅依赖于生物学、医学和化学基础课程通常所引发的理解。结果表明，药代动力学分析的评价只能在这些学科中的任何一个或所有学科的背景下进行解释。没有这种背景，药代动力学结果可能仍然只是对未知机制的数学描述。
