Schneider B
Arzneimittelforschung. 1977 Feb;27(2A):257-64.
Biometrics is the science of mathematical models for biological processes and of methods for the design and analysis of biological experiments. By these tasks the role of the biometrician in the problem of dose-scheduling is determined. He has to develope mathematical models for the dose-response relationship and methods for the design and analysis of pharmacological and clinical experiments. In the paper the probit and logit model are discussed as examples of the mathematical approach to dose-response relationship. The problems of planning and analyzing bioassays are demonstrated. The pharmacological results can be applied to clinical investigations if they are related to standard drugs. The safety or risk of a drug can be measured by the therapeutic index, which is most important for the connection between pharmacological and clinical results. Finally the problem of repeated doses and accumulation is dealt with.
生物统计学是关于生物过程数学模型以及生物实验设计与分析方法的科学。通过这些任务确定了生物统计学家在剂量安排问题中的作用。他必须开发剂量反应关系的数学模型以及药理和临床实验的设计与分析方法。本文讨论了概率单位模型和对数单位模型，作为剂量反应关系数学方法的示例。展示了生物测定的规划和分析问题。如果药理结果与标准药物相关，那么这些结果可应用于临床研究。药物的安全性或风险可以通过治疗指数来衡量，这对于药理结果与临床结果之间的联系最为重要。最后讨论了重复给药和蓄积问题。
