Spronk Peter E, Ince Can, Gardien Martin J, Mathura Keshen R, Oudemans-van Straaten Heleen M, Zandstra Durk F
Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands.
Lancet. 2002 Nov 2;360(9343):1395-6. doi: 10.1016/s0140-6736(02)11393-6.
In patients with septic shock, oxygen consumption is increased, but oxygen delivery and extraction is impaired, partly because of microcirculatory shutdown and shunting. Orthogonal polarisation spectral (OPS) imaging allows visualisation of the microcirculation. We used this technique to assess microcirculatory flow in septic-shock patients who had a mean arterial blood pressure of more than 60 mm Hg and central venous pressure greater than 12 mm Hg. The infusion of 0.5 mg of nitroglycerin intravenously then resulted in a marked increase in microvascular flow on OPS imaging. Improved recruitment of the microcirculation could be a new resuscitation endpoint in septic shock.
在感染性休克患者中，氧耗增加，但氧输送和氧摄取受损，部分原因是微循环关闭和分流。正交偏振光谱（OPS）成像可使微循环可视化。我们使用该技术评估平均动脉血压超过60 mmHg且中心静脉压大于12 mmHg的感染性休克患者的微循环血流。然后静脉输注0.5 mg硝酸甘油导致OPS成像上的微血管血流显著增加。改善微循环的恢复可能是感染性休克新的复苏终点。
