Kinnell H G, Gibbs N, Teale J D, Smith J
Psychol Med. 1987 May;17(2):387-92. doi: 10.1017/s0033291700024946.
This study of 111 institutionalised Down's syndrome subjects and 74 controls found a relatively low risk of hypothyroidism in both groups compared with certain other studies of Down's subjects, which found very high rates of thyroid hypofunction. However, the Down's syndrome group had a significantly raised risk of hypothyroidism (9%), hyperthyroidism (1.8%) and the presence of thyroid microsomal antibodies (29%) compared with the controls and with laboratory reference data. It is recommended that thyroid function testing should be routine in older Down's syndrome subjects, with special attention being given to the clinical status of those with microsomal antibodies present.
这项针对111名患有唐氏综合征的机构收容人员和74名对照者的研究发现，与其他一些针对唐氏综合征患者的研究相比，两组人群甲状腺功能减退的风险相对较低，其他研究发现甲状腺功能减退的发生率非常高。然而，与对照组及实验室参考数据相比，唐氏综合征组甲状腺功能减退（9%）、甲状腺功能亢进（1.8%）及甲状腺微粒体抗体阳性（29%）的风险显著升高。建议对年龄较大的唐氏综合征患者进行常规甲状腺功能检测，尤其要关注那些存在微粒体抗体者的临床状况。
