Fahlander Kjell, Wahlin Ake, Almkvist Ove, Bäckman Lars
Stockholm Gerontology Research Center and NEUROTEC, Division of Geriatric Epidemiology, Karolinska Institute, Stockholm, Sweden.
J Clin Exp Neuropsychol. 2002 Sep;24(6):734-44. doi: 10.1076/jcen.24.6.734.8404.
The purpose of the present study was to examine possible differences in patterns of cognitive performance between population-based samples of Alzheimer's disease (AD; n = 51) and vascular dementia (AD; n = 14) patients between 75 and 96 years of age. The two demented groups were comparable in age, years of education, gender distribution, and severity of dementia. The selection of cognitive tasks (letter and category fluency, Block design, Clock reading and setting, and episodic face recognition) was thought to address some of the inconsistencies in previous research. The main finding was that AD and AD patients were comparable on most tasks, although robust dementia-related deficiencies were found when comparing the results of the demented participants with those of the control participants. These findings suggest that AD and AD may affect several basic cognitive functions in an equal manner.
本研究的目的是检验年龄在75至96岁之间的阿尔茨海默病(AD;n = 51)和血管性痴呆(VaD;n = 14)患者的基于人群样本在认知表现模式上可能存在的差异。这两组痴呆患者在年龄、受教育年限、性别分布和痴呆严重程度方面具有可比性。认知任务(字母流畅性和类别流畅性、积木设计、时钟读取和设置以及情景面孔识别)的选择旨在解决先前研究中的一些不一致之处。主要发现是,AD和VaD患者在大多数任务上具有可比性,尽管在将痴呆参与者的结果与对照参与者的结果进行比较时发现了与痴呆相关的明显缺陷。这些发现表明,AD和VaD可能以相同的方式影响几种基本认知功能。