肝移植术后曲霉菌性骨髓炎

Aspergillus osteomyelitis after liver transplantation.

作者信息

Kaneko Junichi, Sugawara Yasuhiko, Makuuchi Masatoshi

机构信息

Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

出版信息

Liver Transpl. 2002 Nov;8(11):1073-5. doi: 10.1053/jlts.2002.35778.

DOI:10.1053/jlts.2002.35778

PMID:12424724

Abstract

A 57-year-old woman underwent liver transplantation and developed osteomyelitis in the femur attributable to Aspergillus fumigatus. The patient was treated successfully with amphotericin B and 5-fluorocytosine for 30 days, and then switched to itraconazole for 12 months. Plasma (1->3)-beta-D-glucan levels decreased significantly after the chemotherapy. Early diagnosis by (1->3)-beta-D-glucan measurement and extended treatment with itraconazole can improve the prognosis of invasive Aspergillus infection.

摘要

一名57岁女性接受了肝移植，并发由烟曲霉引起的股骨骨髓炎。患者接受两性霉素B和5-氟胞嘧啶治疗30天，治疗成功，随后改用伊曲康唑治疗12个月。化疗后血浆（1->3）-β-D-葡聚糖水平显著下降。通过测量（1->3）-β-D-葡聚糖进行早期诊断并延长伊曲康唑治疗时间可改善侵袭性曲霉感染的预后。