Raja Nadeem Sajjad, Singh Nishi Nihar
Department of Medical Microbiology, University of Malaya Medical Center, Kuala Lumpur, Malaysia.
J Microbiol Immunol Infect. 2006 Feb;39(1):73-7.
Aspergillosis is a spectrum of diseases caused by members of the genus Aspergillus that continues to pose a significant threat to immunocompromised, organ transplant, neutropenic and cancer patients. In view of increasing risk factors leading to invasive aspergillosis, it is imperative for clinicians to be familiar with the clinical presentation, diagnostic methods and management of the disease. We describe a 34-year-old immunocompetent male patient receiving chemotherapy for Aspergillus fumigatus infection that had disseminated to lung, liver and spleen. A computed tomogram of thorax and abdomen showed thick-walled cavities of different sizes with air fluid levels, consolidation in both lungs and involvement of liver and spleen. His broncheoalveolar lavage and sputum specimens yielded A. fumigatus. Successful treatment of this infection was achieved with amphotericin B and itraconazole.
曲霉病是由曲霉属成员引起的一系列疾病，继续对免疫功能低下、器官移植、中性粒细胞减少和癌症患者构成重大威胁。鉴于导致侵袭性曲霉病的危险因素不断增加，临床医生必须熟悉该疾病的临床表现、诊断方法和治疗。我们描述了一名34岁免疫功能正常的男性患者，因烟曲霉感染接受化疗，感染已扩散至肺、肝和脾。胸部和腹部计算机断层扫描显示不同大小的厚壁空洞，伴有气液平面，双肺实变，肝脾受累。他的支气管肺泡灌洗和痰液标本培养出烟曲霉。使用两性霉素B和伊曲康唑成功治疗了该感染。
