Yamamoto H, Yoshino T
Natl Inst Anim Health Q (Tokyo). 1975 Fall;15(3):139-50.
A pathological study was carried out on six calves 4 to 10 months of age affected with lymphoid tumors. Most of the lymph nodes enlarged in consequence of leukotic changes in all the calves. These changes occurred also in other various organs. When the leukotic lesions were investigated to clarify the distribution and histological manifestation, three pathological patterns were discriminated among them. One of the patterns was seen in four cases, in which leukotic lesions were present constantly in bone marrow, thymus, liver and kidney. In the lymph nodes, tonsils, and intestinal lymphatic apparatus, neoplastic cellular proliferation took place in paracortical or interfollicular areas and medullary cords obliterating the lymph follicles. Leukotic involvement was observed in the interstitial and the vascular connective tissue in the thymus, as well as in liver and kidney. A second pattern of lesion was revealed in one of the other two cases. Besides lymph nodes in which neoplastic proliferation was seen in the paracortical area, only the thymus manifested intralobular neoplastic involvement in this case. In the remaining case, the leukotic lesion was characterized by the presence of neoplastic cellular masses resembling large lymph follicles in appearance in the lymphatic tissues. It was manifested distinctly in the spleen. Severe thymic atrophy and granulocytic hyperplasia in bone marrow were present in this case.
对6头4至10月龄患淋巴样肿瘤的犊牛进行了病理研究。所有犊牛的大多数淋巴结因白血病性变化而肿大。这些变化也发生在其他各种器官中。当对白血病性病变进行研究以明确其分布和组织学表现时，在其中鉴别出了三种病理模式。其中一种模式见于4例，白血病性病变在骨髓、胸腺、肝脏和肾脏中持续存在。在淋巴结、扁桃体和肠道淋巴组织中，肿瘤细胞增殖发生在副皮质区或滤泡间区以及髓索，使淋巴滤泡消失。在胸腺以及肝脏和肾脏的间质和血管结缔组织中观察到白血病性浸润。在另外两例中的一例中发现了第二种病变模式。除了在副皮质区可见肿瘤性增殖的淋巴结外，该病例中仅胸腺表现为小叶内肿瘤性浸润。在其余病例中，白血病性病变的特征是在淋巴组织中存在外观类似大淋巴滤泡的肿瘤细胞团块。在脾脏中表现明显。该病例存在严重的胸腺萎缩和骨髓粒细胞增生。
