Yamamoto H, Yoshino T, Matsuda I, Nakajima H
Natl Inst Anim Health Q (Tokyo). 1982 Fall;22(3):115-29.
Histopathological distinctions were examined on 36 cattle 2 months to 12 years of age affected with leukosis. The distribution of tumors pointed out previously as the characteristic of the adult type of leukosis was observed in 27 adult cases, which, except two, were positive for the immunodiffusion test of bovine leukemia virus (BLV). The noticeable development of massive and lumpy tumors in serosa, loose connective tissue, and lymph nodes seemed to suggest a neoplastic accumulation in areas related to the lymphatic way. Splenic involvement and intrasinusoidal leukotic immigration in the liver were present in cases with the leukemic manifestation of peripheral blood. The neoplastic involvement of bone marrow, however, was difficult to find. On the other hand, in 5 calves and 4 adolescent or adult cattle, the neoplastic proliferation was observed throughout such hematopoietic organs as lymph nodes, bone marrow, liver, spleen, thymus and tonsil. The hepatic lesion was characterized by the neoplastic proliferation in the portal triads No BLV antibody could be detected from these cattle, except one adult. As the conclusion of the present study, the tumor of adult type regarded as the pathologic manifestation of enzootic bovine leukosis is defined as malignant lymphoma (non-Hodgkin's lymphoma or lymphosarcoma) of undifferentiated-, histiocytic-, or poorly- differentiated lymphocytic- cell type. And lymphocytic leukemia seems to be desirable term to distinguish the lymphoid malignancy regarded as the characteristic of the calf type from that of the adult type.
对36头2月龄至12岁患白血病的牛进行了组织病理学鉴别。在27例成年病例中观察到了先前指出的作为成年型白血病特征的肿瘤分布，除两例外，这些病例的牛白血病病毒（BLV）免疫扩散试验呈阳性。浆膜、疏松结缔组织和淋巴结中大量块状肿瘤的明显发展似乎表明在与淋巴途径相关的区域有肿瘤积聚。外周血出现白血病表现的病例存在脾脏受累和肝脏窦内白血病细胞浸润。然而，骨髓的肿瘤累及很难发现。另一方面，在5头犊牛和4头青少年或成年牛中，在淋巴结、骨髓、肝脏、脾脏、胸腺和扁桃体等造血器官中均观察到肿瘤性增殖。肝脏病变的特征是门三联区的肿瘤性增殖。除1例成年牛外，这些牛均未检测到BLV抗体。作为本研究的结论，被视为地方流行性牛白血病病理表现的成年型肿瘤被定义为未分化型、组织细胞型或低分化淋巴细胞型的恶性淋巴瘤（非霍奇金淋巴瘤或淋巴肉瘤）。淋巴细胞白血病似乎是一个合适的术语，用于区分被视为犊牛型特征的淋巴样恶性肿瘤和成年型淋巴样恶性肿瘤。
