Tourneur R, Letonturier P
Minerva Med. 1975 Nov 14;66(77):4048-52.
Hashimoto's thyroiditis is a polymorphous condition. Its clinical diagnosis depends on the presence of a moderately large goitre of recent onset (2-3 yr) that is usually symmetrical and node-free, and particularly hard and rubbery. In addition, a high level of antithyroid antibodies is observed. A search for these antibodies should certainly be made more often. Histological confirmation is required as soon as the level of antibodies is low, or when the goitre is nodular with cold scintiscan areas. Furthermore, development of the intrathyroid lymphoid system is of uncertain import, especially since there is no relation between the number of cells that could theoretically be secreting antibodies (i.e. intrathyroid plasma cells) and the incidence or level of the various antithyroid antibodies.
桥本甲状腺炎是一种多形性疾病。其临床诊断取决于近期发病（2 - 3年）的中度肿大甲状腺，通常对称且无结节，质地特别硬且呈橡皮样。此外，可观察到高水平的抗甲状腺抗体。确实应该更频繁地检测这些抗体。一旦抗体水平较低，或者甲状腺肿有结节且甲状腺闪烁扫描显示冷结节区域时，就需要进行组织学确诊。此外，甲状腺内淋巴系统的发育意义尚不明确，特别是因为理论上可能分泌抗体的细胞（即甲状腺内浆细胞）数量与各种抗甲状腺抗体的发生率或水平之间并无关联。
