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[脊柱骨髓瘤的外科治疗,附19例报告]

[Surgical treatment of spinal myeloma, report of 19 cases].

作者信息

Xu Hongguang, Wang Yipeng, Qiu Guixing, Ye Qibin, Zhang Jia

机构信息

Department Of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2002 Aug 25;82(16):1118-20.

Abstract

OBJECTIVES

To discuss the indications for surgical procedures of spinal myeloma.

METHODS

A retrospective analysis was made of the data of operation results of Nineteen patients with spinal myeloma, 13 males and 6 females, with the mean age of 45.1 (range 31 approximately 52). Pain was present in all patients. Nine patients had neurological deficit. According to Frankel classification 5 cases were Frankel B, 3 cases were Frenkel C, and 1 case was Frenkel D. Fourteen cases were diagnosed before operation, and 5 cases were diagnosed by pathology after operation. Surgical procedures performed included anterior approach in 11 cases, posterior approach in 7 cases and combined approach in 1 case.

RESULTS

Decrease of pain was observed in all cases after surgery. Neurological improvement was observed in 8 out of the 9 cases. Complication (alteration of intestinal flora) occurred in one case. Follow-up lasted more than 1 year except in one case with a follow-up of only 6 months. Four cases were lost of follow-up. One case was still alive during the follow-up 8 years after operation. Other cases survived for 26.5 months on average (range 16 approximately 48 months).

CONCLUSION

Surgery can ensure neurological improvement and spinal stability for patients with spinal myeloma, but should be associated with adjunctive medical treatment.

摘要

目的

探讨脊柱骨髓瘤手术治疗的适应证。

方法

回顾性分析19例脊柱骨髓瘤患者的手术结果资料,其中男性13例,女性6例,平均年龄45.1岁(范围31至52岁)。所有患者均有疼痛症状。9例患者存在神经功能缺损。根据Frankel分级,5例为Frankel B级,3例为Frenkel C级,1例为Frenkel D级。14例患者术前确诊,5例患者术后经病理确诊。手术方式包括前路手术11例,后路手术7例,前后联合手术1例。

结果

所有患者术后疼痛均减轻。9例神经功能缺损患者中,8例神经功能改善。1例患者发生并发症(肠道菌群改变)。除1例患者随访仅6个月外,其余患者随访时间均超过1年。4例患者失访。1例患者术后8年随访时仍存活。其他患者平均存活26.5个月(范围16至48个月)。

结论

手术可确保脊柱骨髓瘤患者神经功能改善及脊柱稳定性,但应联合辅助药物治疗。

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