Zhang Ke, Ma Daqing, Xu Bin, Zhao Dawei, Wu Hao, Hua Liwei, Qin Shulin, Xu Lianzhi
Beijing Youan Hospital, Beijing 100054, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2002 Aug;25(8):475-7.
To explore the clinical characteristics and the diagnostic methods for PCP in patients with AIDS.
Twelve cases of AIDS associated PCP confirmed by sputum polymerase chain reaction (PCR) were analyzed.
Tuberculosis was found in 4 cases and pneumonia in 1 case of PCP. Sputum PCR was positive in all the 12 cases, of them blood PCR was positive in 9, Gomori methenamine silver stain (GMS) positive in 5 and Giemsa stain positive in 6 cases. The CD(4)(+) lymphocyte count was (5 approximately 155) x 10(6)/L, with a mean of (51 +/- 48) x 10(6)/L; the number of CD(4)(+) cells less than 100 x 10(6)/L in 10 cases (83%) with 9 cases (75%) less than 50 x 10(6)/L. The CD(4)(+)/CD(8)(+) ratio was 0.01 approximately 0.29.
PCP was common in patients with advanced AIDS and often co-infected with other opportunistic infections such as tuberculosis. A diagnosis of PCP should be considered if sputum PCR is positive and typical clinical manifestations are present in patients with AIDS.
探讨艾滋病患者肺孢子菌肺炎（PCP）的临床特点及诊断方法。
分析12例经痰聚合酶链反应（PCR）确诊的艾滋病合并PCP患者的情况。
12例PCP患者中，4例合并肺结核，1例合并肺炎。12例痰PCR均为阳性，其中9例血PCR阳性，5例吉姆萨染色阳性，6例六胺银染色阳性。CD4+淋巴细胞计数为（5～155）×10⁶/L，平均为（51±48）×10⁶/L；10例（83%）CD4+细胞数小于100×10⁶/L，9例（75%）小于50×10⁶/L。CD4+/CD8+比值为0.01～0.29。
PCP在晚期艾滋病患者中常见，且常合并其他机会性感染如肺结核。艾滋病患者痰PCR阳性且有典型临床表现时应考虑PCP诊断。
