Mitnitski Arnold B, Mogilner Alexander J, MacKnight Chris, Rockwood Kenneth
Department of Medicine, Dalhousie University, Halifax NS, Canada.
Mech Ageing Dev. 2002 Sep;123(11):1457-60. doi: 10.1016/s0047-6374(02)00082-9.
In a representative Canadian population survey (n=66589) the proportion of accumulated deficits in a frailty index showed a linear relationship with mortality in a log-log plot, such that the mortality rate was a power-law function of the frailty index. Represented in this way, the frailty index readily summarizes individual differences in health status. The exponent and amplitude parameters of the power function are gender specific, reflecting that while, on average, women accumulate more deficits than men of the same age, their risk of mortality is lower. The dependence of the mortality rate on the frailty index points to the merit of the index as a simple and accessible tool for estimating individual risks of mortality.
在一项具有代表性的加拿大人口调查(n = 66589)中,衰弱指数累积缺陷的比例在对数-对数图中与死亡率呈现线性关系,即死亡率是衰弱指数的幂律函数。以这种方式表示,衰弱指数能够轻松概括个体健康状况的差异。幂函数的指数和幅度参数具有性别特异性,这反映出虽然平均而言,同龄女性比男性积累的缺陷更多,但她们的死亡风险更低。死亡率对衰弱指数的依赖性表明该指数作为一种简单且易于获取的工具来估计个体死亡风险具有价值。