在扫描前给予阿片类药物会延长核肝胆显像时间。

Opioids prolong nuclear hepatobiliary imaging when given prior to scanning.

作者信息

Barlas David, Margouleff Donald, Vignogna-Barlas Lisa, Lesser Martin L

机构信息

Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, New York 11030, USA.

出版信息

J Emerg Med. 2002 Oct;23(3):231-6. doi: 10.1016/s0736-4679(02)00523-1.

DOI:10.1016/s0736-4679(02)00523-1

PMID:12426012

Abstract

Opioid-mediated contraction of the distal common bile duct (CBD) may delay tracer passage during nuclear hepatobiliary imaging (NHI), mimicking pathologic obstruction. We sought to determine if opioid administration before NHI delays CBD visualization and prolongs imaging. The records of 198 Emergency Department patients who underwent NHI were reviewed (after excluding those with evidence for pathologic CBD obstruction). Opioids were administered before NHI in 56 cases. Delayed CBD visualization occurred in 28.6% of subjects who had received opioids and in 12.0% of those who had not (p < 0.01). Delayed imaging was performed in 77.8% of those who had received opioids and in 53.5% of those who had not (p < 0.01). The relative risk of delayed CBD visualization was 1.46 [95%CI 0.65-3.28] for meperidine, 4.18 [95%CI 2.00-8.82] for morphine, and 2.38 [95%CI 1.29-4.39] for any opioid. We conclude that opioids given before NHI are associated with delayed CBD visualization and more imaging sessions.

摘要

阿片类药物介导的胆总管远端（CBD）收缩可能会在核肝胆显像（NHI）期间延迟示踪剂通过，模拟病理性梗阻。我们试图确定在NHI前给予阿片类药物是否会延迟CBD显影并延长成像时间。回顾了198例接受NHI的急诊科患者的记录（排除那些有CBD病理性梗阻证据的患者）。56例患者在NHI前给予了阿片类药物。接受阿片类药物的患者中28.6%出现CBD显影延迟，未接受阿片类药物的患者中这一比例为12.0%（p<0.01）。接受阿片类药物的患者中77.8%进行了延迟成像，未接受阿片类药物的患者中这一比例为53.5%（p<0.01）。哌替啶导致CBD显影延迟的相对风险为1.46[95%CI 0.65 - 3.28]，吗啡为4.18[95%CI 2.00 - 8.82]，任何阿片类药物为2.38[95%CI 1.29 - 4.39]。我们得出结论，在NHI前给予阿片类药物与CBD显影延迟和更多的成像检查相关。