Schünemann Holger J, Guyatt Gordon H, Griffith Lauren, Stubbing David, Goldstein Roger
Department of Medicine, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, NY, USA.
Chest. 2002 Nov;122(5):1701-8. doi: 10.1378/chest.122.5.1701.
Previous studies with short recall periods have suggested that informed administration (previous responses available) may improve the responsiveness and validity of health-related quality-of-life (HRQL) questionnaires in comparison to blind administration (previous responses unavailable). Informed administration may, however, have less impact in studies with longer recall periods. The objective of this randomized trial was to compare the validity and responsiveness of the blind and informed Chronic Respiratory Questionnaire (CRQ) and the St. George's Respiratory Questionnaire (SGRQ) with a 3-month interval between questionnaire completion.
We randomized 85 patients to blind or informed administration of the CRQ and SGRQ before and after they underwent a standard respiratory rehabilitation program. Patients also completed other HRQL instruments.
At the follow-up administration, we observed important and statistically significant improvement in all four CRQ domains and three SGRQ domains. The results of blind and informed administration differed little. This was true for both the CRQ and the SGRQ, and for both responsiveness and validity.
In contrast to the improved measurement properties after shorter recall periods, the administration of the informed version after > or = 12 weeks may not result in improvements in responsiveness or validity.
既往短期回忆期的研究表明，与盲法施测（无法获取先前的回答）相比，告知施测（可获取先前的回答）可能会提高健康相关生活质量（HRQL）问卷的反应性和效度。然而，在回忆期较长的研究中，告知施测的影响可能较小。这项随机试验的目的是比较在问卷完成间隔3个月的情况下，盲法和告知施测的慢性呼吸问卷（CRQ）及圣乔治呼吸问卷（SGRQ）的效度和反应性。
我们将85例患者随机分为两组，在他们接受标准呼吸康复计划之前和之后，分别对其进行盲法或告知施测的CRQ和SGRQ。患者还完成了其他HRQL工具。
在随访施测时，我们观察到CRQ的所有四个领域和SGRQ的三个领域均有重要且具有统计学意义的改善。盲法和告知施测的结果差异不大。CRQ和SGRQ均如此，反应性和效度方面都是如此。
与较短回忆期后测量特性有所改善不同，在≥12周后进行告知版本的施测可能不会提高反应性或效度。
