Edsberg Laura E, Brogan Michael S, Jaynes C David, Fries Kristin
Natural and Health Sciences Research Center, Daemen College, 4380 Main Street, Amherst, NY 14226, USA.
Ostomy Wound Manage. 2002 Nov;48(11):42-50.
Treatment of chronic wounds involves interventions ranging from dressings to surgery. Modalities gaining popularity in clinical settings include topical hyperbaric oxygen and electrical stimulation. A prospective, uncontrolled study was conducted to obtain preliminary observations and data about the effects of topical hyperbaric oxygen therapy and topical hyperbaric oxygen used with electrical stimulation on the healing of chronic wounds. All subjects were geriatric residents of long-term care facilities with Stage III or Stage IV pressure ulcers. Topical hyperbaric oxygen was applied daily to the wounds of eight subjects; three also received electrical stimulation. Initial wound size ranged from 87.75 cm2 to 7.04 cm2 with an average size of 30.1 +/- 28.5 (mean +/- sd) cm2. Healing times ranged from 8 to 49 weeks. After 4 weeks of treatment with topical hyperbaric oxygen, wound size decreased an average of 34.4% +/- 22.9%. Incidentally, the wounds of five of the eight subjects decreased more than 20%, for an average of 51.8% +/- 17.9%. No significant differences in healing were observed between patients receiving topical hyperbaric oxygen alone and those receiving topical hyperbaric oxygen/electrical stimulation. Preliminary data indicate that topical hyperbaric oxygen facilitates wound healing and full closure for pressure ulcers in patients with and without diabetes mellitus. A multicenter, prospective, randomized, double-blind controlled study is currently under way.
慢性伤口的治疗包括从敷料到手术等一系列干预措施。在临床环境中越来越受欢迎的治疗方式包括局部高压氧治疗和电刺激。进行了一项前瞻性、非对照研究，以获取关于局部高压氧治疗以及局部高压氧联合电刺激对慢性伤口愈合影响的初步观察结果和数据。所有受试者均为长期护理机构中的老年居民，患有Ⅲ期或Ⅳ期压疮。对8名受试者的伤口每日进行局部高压氧治疗；其中3名还接受了电刺激。初始伤口面积在87.75平方厘米至7.04平方厘米之间，平均面积为30.1±28.5（均值±标准差）平方厘米。愈合时间在8至49周之间。局部高压氧治疗4周后，伤口面积平均减少了34.4%±22.9%。顺便提一下，8名受试者中有5人的伤口减少超过20%，平均减少了51.8%±17.9%。在仅接受局部高压氧治疗的患者与接受局部高压氧/电刺激治疗的患者之间，未观察到愈合方面的显著差异。初步数据表明，局部高压氧有助于糖尿病患者和非糖尿病患者压疮的伤口愈合和完全闭合。一项多中心、前瞻性、随机、双盲对照研究正在进行中。
