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[药物与母乳喂养]

[Drugs and breastfeeding].

作者信息

Prokopczyk Jadwiga, Kaminska Ewa

机构信息

Zaklad Farmakologii, Instytut Matki i Dziecka, ul. Kasprzaka 17a, Warszawa, Poland.

出版信息

Med Wieku Rozwoj. 2002 Apr-Jun;6(2):135-44.

Abstract

Most drugs taken by the mother reach breast milk and are ingested by the nursing infant. Most of the drugs are detected in breast milk at low concentrations, so breastfeeding by women taking these drugs is possible. The effect of some drugs on the nursing infant is unknown and further studies are needed. Some drugs may achieve significant infant plasma concentrations and may be unsafe for the infant. In these cases the infant should be carefully monitored for any clinical side effects and whenever observed, breastfeeding should be discontinued. Despite the confirmed benefits of breastfeeding, there are certain drugs which are absolutely contraindicated; in these cases interruption of breastfeeding is necessary. This review summarises the current scientific knowledge on compatibility of drugs with breastfeeding, focusing on drugs that are contraindicated and of which use in breastfeeding remains controversial.

摘要

母亲服用的大多数药物会进入母乳,并被哺乳婴儿摄入。大多数药物在母乳中的浓度较低,因此服用这些药物的女性可以进行母乳喂养。一些药物对哺乳婴儿的影响尚不清楚,需要进一步研究。一些药物可能会在婴儿血浆中达到显著浓度,对婴儿可能不安全。在这些情况下,应仔细监测婴儿是否有任何临床副作用,一旦观察到,就应停止母乳喂养。尽管母乳喂养有已被证实的益处,但仍有某些药物绝对禁忌;在这些情况下,中断母乳喂养是必要的。本综述总结了目前关于药物与母乳喂养兼容性的科学知识,重点关注禁忌药物以及母乳喂养中使用仍存在争议的药物。

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