人类慢性曼氏血吸虫病患者治疗前后针对虫卵抗原的抗体亚型反应。
Antibody isotype responses to egg antigens in human chronic Schistosomiasis mansoni before and after treatment.
作者信息
Gomes Yara M, Pereira Valéria R A, Nakazawa Mineo, Montarroyos Ulisses, Souza Wayner V, Abath Frederico G C
机构信息
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, PE, 50670-420, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2002;97 Suppl 1:111-2. doi: 10.1590/s0074-02762002000900022.
In the present communication we analyzed the levels of IgG1, IgG2, IgG3, IgG4 and IgE isotypes to soluble egg antigen of Schistosoma mansoni by ELISA in individuals from an endemic area for schistosomiasis in Northeast Brazil. The analysis was performed before and after treatment to evaluate the age-dependent pattern, and to identify differences in the reactivities to antigens. Our results suggest that schistosomiasis treatment would not interfere with this sort of immune response.
在本报告中，我们通过酶联免疫吸附测定法（ELISA）分析了巴西东北部血吸虫病流行地区个体中针对曼氏血吸虫可溶性虫卵抗原的IgG1、IgG2、IgG3、IgG4和IgE同种型水平。在治疗前后进行了分析，以评估年龄依赖性模式，并确定对抗原反应性的差异。我们的结果表明，血吸虫病治疗不会干扰这种免疫反应。
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