Viana I R, Correa-Oliveira R, Carvalho O dos S, Massara C L, Colosimo E, Colley D G, Gazzinelli G
Centro de Pesquisas René Rachou (FIOCRUZ) CP 1743, Belo Horizonte, MG, Brazil.
Parasite Immunol. 1995 Jun;17(6):297-304. doi: 10.1111/j.1365-3024.1995.tb00895.x.
The isotypic patterns of antibodies against Schistosoma mansoni antigenic preparations from eggs (SEA), adult worms (SWAP) and cercariae (CERC) have been studied in sera from two groups of individuals living in an area endemic for S. mansoni. One of the groups was comprised of individuals diagnosed as having S. mansoni infections based on their patency, i.e. those passing eggs in their faeces (patent infections, PI). The other group has been consider 'putatively resistant' due to their residence in an endemic area, their documented exposure to positive transmission sites, and their repeated negativity upon stool examinations (endemic normals, EN). There are strong specific responses of IgG1, IgG4 and IgM, particularly to SEA and CERC, by both groups. The reactivities of all isotypes were lower to SWAP. The responses of IgG4, IgM and IgE anti-CERC in EN and PI are higher than those found in normal individuals from outside endemic areas. In general, EN individuals express a relative higher level of anti-STEG IgE as compared to IgG4. On the other hand the pool of sera from PI showed the opposite pattern of higher IgG4 as compared to IgE. Several correlations are seen between isotypic responses to SEA, SWAP and CERC based on comparisons to the anti-SWAP IgE responses of the individuals in the two groups. These comparisons indicate the presence of distinct immunologic differences between individuals in the PI and the EN groups.
对来自曼氏血吸虫虫卵（SEA）、成虫（SWAP）和尾蚴（CERC）抗原制剂的抗体同型模式，已在生活于曼氏血吸虫流行区的两组个体的血清中进行了研究。其中一组由根据粪便中虫卵排出情况确诊为曼氏血吸虫感染的个体组成，即粪便中排出虫卵的个体（显性感染，PI）。另一组由于居住在流行区、有记录表明接触过阳性传播地点且粪便检查反复呈阴性，被认为是“推定抗性个体”（地方性正常个体，EN）。两组对SEA和CERC均有强烈的IgG1、IgG4和IgM特异性反应。所有同型抗体对SWAP的反应性较低。EN组和PI组中针对CERC的IgG4、IgM和IgE反应高于非流行区正常个体。总体而言，与IgG4相比，EN个体表达的抗STEG IgE水平相对较高。另一方面，PI组血清显示出与IgE相比IgG4更高的相反模式。基于与两组个体抗SWAP IgE反应的比较，观察到针对SEA、SWAP和CERC的同型反应之间存在若干相关性。这些比较表明PI组和EN组个体之间存在明显的免疫学差异。
