Mutapi Francisca, Mduluza Takafira, Ndhlovu Patricia D
Department of Veterinary Clinical Studies, Veterinary School, University of Glasgow, UK.
Mem Inst Oswaldo Cruz. 2002;97 Suppl 1:173-80. doi: 10.1590/s0074-02762002000900034.
The effect of praziquantel treatment on the age-antibody relationship was studied in 174 children aged between 6 and 17 years from a schistosome endemic area in Zimbabwe. The children were co-infected with Schistosoma mansoni and S. haematobium with infection prevalences of 74% and 53% respectively. Antibody levels for the isotypes IgA, IgE, IgM, IgG1, IgG2, IgG3 and IgG4, directed against soluble egg antigen were measured using an indirect ELISA assay. Treatment resulted in a significant increase in levels of IgG2 and IgG3 while levels of IgA decreased significantly. In untreated children there were significant decreases in levels of IgG4. Treatment also resulted in significant alteration in the age-antibody profiles for the isotypes IgE, IgM, IgG1 and IgG2 in treated children but not in untreated children. The results are discussed in the context of factors believed to give rise to the age-antibody relationship; i.e. age-related exposure patterns, age-related development of acquired immunity, age-related hormonal changes and age-related changes in innate susceptibility to infection.
在津巴布韦一个血吸虫病流行地区，对174名6至17岁儿童进行了研究，以探讨吡喹酮治疗对年龄与抗体关系的影响。这些儿童同时感染了曼氏血吸虫和埃及血吸虫，感染率分别为74%和53%。使用间接酶联免疫吸附测定法测量针对可溶性虫卵抗原的IgA、IgE、IgM、IgG1、IgG2、IgG3和IgG4等亚型的抗体水平。治疗导致IgG2和IgG3水平显著升高，而IgA水平显著下降。在未治疗的儿童中，IgG4水平显著降低。治疗还导致治疗组儿童中IgE、IgM、IgG1和IgG2亚型的年龄-抗体谱发生显著变化，而未治疗组儿童则未出现这种变化。研究结果结合被认为导致年龄与抗体关系的因素进行了讨论，即与年龄相关的接触模式、获得性免疫的年龄相关发展、与年龄相关的激素变化以及对感染的先天易感性的年龄相关变化。
