Amorim Fábio Ferreira, Pinheiro Bd Bruno do Vale, Romaldini Hélio
Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
Arq Bras Cardiol. 2002 Oct;79(4):395-404. doi: 10.1590/s0066-782x2002001300007.
To analyze hemodynamic and metabolic effects of saline solution infusion in the maintenance of blood volume in ischemia-reperfusion syndrome during temporary abdominal aortic occlusion in dogs.
We studied 20 dogs divided into 2 groups: the ischemia-reperfusion group (IRG, n=10) and the ischemia-reperfusion group with saline solution infusion aiming at maintaining mean pulmonary arterial wedge pressure between 10 and 20 mmHg (IRG-SS, n=10). All animals were anesthetized with sodium thiopental and maintained on spontaneous ventilation. Occlusion of the supraceliac aorta was obtained with inflation of a Fogarty catheter inserted through the femoral artery. After 60 minutes of ischemia, the balloon was deflated, and the animals were observed for another 60 minutes of reperfusion.
IRG-SS dogs did not have hemodynamic instability after aortic unclamping, and the mean systemic blood pressure and heart rate were maintained. However, acidosis worsened, which was documented by a greater reduction of arterial pH that occurred especially due to the absence of a respiratory response to metabolic acidosis that was greater with the adoption of this procedure.
Saline solution infusion to maintain blood volume avoided hemodynamic instability after aortic unclamping. This procedure, however, caused worsening in metabolic acidosis in this experimental model.
分析在犬腹主动脉临时阻断期间缺血再灌注综合征中输注生理盐水维持血容量的血流动力学和代谢效应。
我们研究了20只犬，分为2组：缺血再灌注组（IRG，n = 10）和旨在将平均肺动脉楔压维持在10至20 mmHg之间的输注生理盐水的缺血再灌注组（IRG - SS，n = 10）。所有动物均用硫喷妥钠麻醉并维持自主通气。通过经股动脉插入的Fogarty导管充气来阻断腹主动脉上段。缺血60分钟后，气囊放气，动物再观察60分钟的再灌注情况。
IRG - SS组犬在主动脉松开后没有血流动力学不稳定，平均体循环血压和心率得以维持。然而，酸中毒加重，这表现为动脉pH值下降更大，尤其是由于采用该方法后对代谢性酸中毒缺乏呼吸反应所致。
输注生理盐水维持血容量可避免主动脉松开后的血流动力学不稳定。然而，在该实验模型中，此方法导致代谢性酸中毒加重。
