Jang Youngho, Shin Hyoung Yong, Kim Jin Mo, Lee Mi Young, Keum Dong Yoon
Department of Anesthesiology and Pain Medicine, School of Medicine and Institute for Medical Science, Keimyung University, Daegu, Korea.
J Korean Med Sci. 2005 Aug;20(4):612-7. doi: 10.3346/jkms.2005.20.4.612.
Intravascular administration of magnesium (Mg) causes vasodilation and increases renal blood flow. The aim of this study was to investigate the renal effect of Mg following unclamping of the supraceliac aorta. Mongrels were divided into two groups, control (group C, n=7) and Mg group (group Mg, n=7). In group Mg, 30 mg/kg MgSO4 was injected as a bolus immediately prior to unclamping the supraceliac aorta and thereafter as an infusion (10 mg/kg/hr). The group C received an equivalent volume of saline solution. Systemic hemodynamics, renal artery blood flow, renal cortical blood flow (RCBF), renal vascular resistance, and renal function were compared. Following the aortic unclamping, cardiac output and RCBF were less attenuated, and the systemic and renal vascular resistance was elevated to a lesser degree in the group Mg compared to the group C. There was no significant difference in the plasma renin activity, serum creatinine and Cystatin-C between the two groups. The present study shows that Mg infusion improves systemic hemodynamics and RCBF after aortic unclamping. However, we did not observe any improvement in renal function when Mg was administered after supraceliac aortic unclamping.
血管内注射镁（Mg）可引起血管舒张并增加肾血流量。本研究的目的是探讨腹主动脉上段夹闭解除后镁对肾脏的影响。杂种犬分为两组，对照组（C组，n = 7）和镁组（Mg组，n = 7）。在Mg组中，在腹主动脉上段夹闭解除前立即静脉推注30mg/kg硫酸镁，然后持续输注（10mg/kg/小时）。C组给予等量的生理盐水。比较两组的全身血流动力学、肾动脉血流量、肾皮质血流量（RCBF）、肾血管阻力和肾功能。与C组相比，腹主动脉夹闭解除后，Mg组的心输出量和RCBF衰减较小，全身和肾血管阻力升高程度较小。两组之间的血浆肾素活性、血清肌酐和胱抑素-C无显著差异。本研究表明，输注镁可改善腹主动脉夹闭解除后的全身血流动力学和RCBF。然而，在腹主动脉上段夹闭解除后给予镁时，我们未观察到肾功能有任何改善。
