Ritschel W A
Arzneimittelforschung. 1975 Sep;25(9):1442-7.
Knowing the necessary minimum inhibitory or minimum effective concentration of a drug dose size and/or dosing interval for multiple dose therapy can be calculated under the assumption that the blood level-time curve of a drug can be described by an open one-compartment or an open two-compartment model, that the drug does not show dose dependent pharmacokinetics for the therapeutic dose range and that the distribution coefficient is applicable for a wide body weight range and age group, excluding severe edemas and obesity. The dose size and dosing interval equations are derived from the minimum blood-level concentration c'min equation in multiple dosing. Substituting c'min by MIC or MEC, cop by D - f/Vd and Vd by delta' - BW either the required dose size or dosing interval can be calculated. In the case of renal failure adjustment can be made by inclusion of a correction factor into the equations using either the observed creatinine clearance or the serum creatinine value.
在假设药物的血药浓度-时间曲线可用开放单室模型或开放双室模型描述、药物在治疗剂量范围内不呈现剂量依赖性药代动力学且分布系数适用于广泛体重范围和年龄组（不包括严重水肿和肥胖症）的情况下，可以计算出多次给药治疗所需的最小抑菌浓度或最小有效浓度、药物剂量大小和/或给药间隔。剂量大小和给药间隔方程由多次给药时的最低血药浓度c'min方程推导得出。用MIC或MEC代替c'min，用D - f/Vd代替cop，用δ' - BW代替Vd，就可以计算出所需的剂量大小或给药间隔。在肾衰竭的情况下，可以通过将校正因子纳入方程来进行调整，校正因子可使用观察到的肌酐清除率或血清肌酐值。
