Hajratwala B R
Pharmazie. 1976;31(10):731-3.
New generalized equations for one compartment open model system with rapid i.v. injections for multiple dose kinetics are developed. The model assumers the first order elimination. Equations are developed for the maximum and minimum amounts of drug in body after n and infinity number of doses. The methods for calculating rate of accumulation is presented and the relationship bewteen, f (fraction of drug present in the compartment at the time of repeated dosing), t1/2 and the dosing interval, tau.
推导了用于多剂量动力学快速静脉注射的一室开放模型系统的新广义方程。该模型假定为一级消除。推导了第n次和无限次给药后体内药物最大量和最小量的方程。给出了计算蓄积率的方法以及f（重复给药时房室中存在的药物分数）、t1/2和给药间隔τ之间的关系。
