Sawayama Yasunori, Nabeshima Shigeki, Taniai Hiroaki, Furusyo Norihiro, Kashiwagi Seizaburo, Hayashi Jun
Department of General Medicine, Kyushu University Hospital, Higashi-ku, Fukuoka 812-8582, Japan.
Fukuoka Igaku Zasshi. 2002 Sep;93(9):189-95.
A 22-year-old man was admitted to our hospital with a high fever, fatigue, mild arthritis, and bilateral pleural effusions. Laboratory tests revealed a high ESR, leukocytosis, high serum C-reactive protein level, and high serum ferritin level. Various antibiotics had been given by a local hospital with no response. He was diagnosed as having severe refractory adult Still's disease and was subsequently treated with high-dose steroid therapy and low-dose cyclosporin A. The serum interleukin-18 level was monitored throughout treatment and was found to be a potentially useful marker of disease activity as well as of the response to cyclosporin A therapy.
一名22岁男性因高热、乏力、轻度关节炎及双侧胸腔积液入院。实验室检查显示血沉增快、白细胞增多、血清C反应蛋白水平升高及血清铁蛋白水平升高。当地医院给予多种抗生素治疗均无效。他被诊断为重症难治性成人斯蒂尔病，随后接受了大剂量类固醇治疗及小剂量环孢素A治疗。在整个治疗过程中监测血清白细胞介素-18水平，发现其是疾病活动及环孢素A治疗反应的潜在有用标志物。
