Hartmann Anders, Jenssen Trond, Midtvedt Karsten, Reisaeter Anna V, Fauchald Per, Henriksen Tore, Monn Eirik, Christophersen Bjørn
Nyreseksjonen Medisinsk avdeling, Rikshospitalet 0027 Oslo.
Tidsskr Nor Laegeforen. 2002 Sep 20;122(22):2180-3.
Proteinuria is an indicator of renal disease. Measurement of protein excretion is important for diagnosis and follow-up of renal disease, but measuring 24-hour protein excretion is a cumbersome procedure.
A simplified validated method for measuring excretion is obtained by measuring urine protein/creatinine concentration in a spot urine sample.
We have implemented such ratios for clinical routine measurements of proteinuria at Rikshospitalet University Hospital in Oslo. Whenever protein or albumin in urine is requested, the laboratory also measures urine creatinine and reports the ratio in mg protein/mmol creatinine. 24-hour excretion is approximately 10 times the ratio. The rationale for using the ratio is given and proteinuria pathophysiology and potential risks and treatment options are discussed.
Our experience is that use of the urine protein/creatinine ratio is a significant improvement. Measurements are now routinely made whereas quantification was rarely performed when 24-hour urine samples were used. We recommend that physicians and laboratories implement the use of this ratio in their daily routines.
蛋白尿是肾脏疾病的一个指标。蛋白质排泄量的测定对于肾脏疾病的诊断和随访很重要，但测量24小时蛋白质排泄量是一个繁琐的过程。
通过测量随机尿样中的尿蛋白/肌酐浓度，获得一种简化的、经过验证的测量排泄量的方法。
我们已在奥斯陆大学医院将此类比值用于蛋白尿的临床常规测量。每当需要检测尿蛋白或白蛋白时，实验室也会测量尿肌酐，并报告以mg蛋白/mmol肌酐为单位的比值。24小时排泄量约为该比值的10倍。给出了使用该比值的基本原理，并讨论了蛋白尿的病理生理学、潜在风险和治疗选择。
我们的经验是，使用尿蛋白/肌酐比值有显著改进。现在常规进行测量，而使用24小时尿样时很少进行定量检测。我们建议医生和实验室在日常工作中采用该比值。
