Schaneberg B T, Applequist W L, Khan I A
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA.
Pharmazie. 2002 Oct;57(10):686-9.
Wild ginger, Asarum canadense, which has folk uses as a medicinal and food plant, has been reported to contain aristolochic acid I. Rhizomes of North American species of Aristolochiaceae were surveyed for the presence of aristolochic acids by HPLC. Aristolochic acid I (1) and aristolochic acid II (2) were present in Aristolochia species and Hexastylis; 1 alone was detected in multiple accessions of A. canadense and Asarum caudatum, though not in Asarum wagneri. Concentrations in A. canadense were highly variable, reaching as much as 0.037 percent of dry weight.
细辛，即加拿大细辛，作为药用和食用植物在民间有应用，据报道其含有马兜铃酸I。通过高效液相色谱法对马兜铃科北美物种的根茎进行了马兜铃酸检测。马兜铃属植物和六棱果细辛属植物中存在马兜铃酸I（1）和马兜铃酸II（2）；在加拿大细辛和尾花细辛的多个样本中仅检测到1，而在瓦格纳细辛中未检测到。加拿大细辛中的含量变化很大，高达干重的0.037%。
