Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Eye Department, J. Strus City Hospital, Szwajcarska 3, 61-285 Poznań, Poland.
Molecules. 2020 Oct 11;25(20):4624. doi: 10.3390/molecules25204624.
Controlled drug delivery is a matter of interest to numerous scientists from various domains, as well as an essential issue for society as a whole. In the treatment of many diseases, it is crucial to control the dosing of a drug for a long time and thus maintain its optimal concentration in the tissue. Heart diseases are particularly important in this aspect. One such disease is an obstructive arterial disease affecting millions of people around the world. In recent years, stents and balloon catheters have reached a significant position in the treatment of this condition. Balloon catheters are also successfully used to manage tear ducts, paranasal sinuses, or salivary glands disorders. Modern technology is continually striving to improve the results of previous generations of stents and balloon catheters by refining their design, structure, and constituent materials. These advances result in the development of both successive models of drug-eluting stents (DES) and drug-eluting balloons (DEB). This paper presents milestones in the development of DES and DEB, which are a significant option in the treatment of coronary artery diseases. This report reviews the works related to achievements in construction designs and materials, as well as preparation technologies, of DES and DEB. Special attention was paid to the polymeric biodegradable materials used in the production of the above-mentioned devices. Information was also collected on the various methods of producing drug release coatings and their effectiveness in releasing the active substance.
控释药物输送是众多来自不同领域的科学家感兴趣的问题，也是整个社会的一个重要问题。在治疗许多疾病时，控制药物的长时间剂量以保持其在组织中的最佳浓度至关重要。心脏病在这方面尤为重要。其中一种疾病是影响全球数百万人的阻塞性动脉疾病。近年来，支架和球囊导管在治疗这种疾病方面取得了显著地位。球囊导管也成功用于治疗泪管、副鼻窦或唾液腺疾病。现代技术不断努力通过改进支架和球囊导管的设计、结构和组成材料来提高前几代的治疗效果。这些进步导致了药物洗脱支架（DES）和药物洗脱球囊（DEB）的连续模型的发展。本文介绍了 DES 和 DEB 的发展里程碑，它们是治疗冠状动脉疾病的重要选择。本报告回顾了与 DES 和 DEB 的构建设计和材料以及制备技术相关的工作。特别关注用于生产上述装置的可生物降解的聚合物材料。还收集了关于生产药物释放涂层的各种方法及其释放活性物质的有效性的信息。
