Gracious Barbara L, Krysiak Tracie E, Youngstrom Eric A
Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 14642, USA.
J Child Adolesc Psychopharmacol. 2002 Fall;12(3):249-57. doi: 10.1089/104454602760386941.
The purpose of this study was to explore whether amantadine would slow or reverse significant weight gain in children and adolescents treated with antipsychotics and/or mood stabilizers that may promote increases in weight.
Eight boys and one girl ages 9-16 years and their parents consented to an open trial of amantadine 100 mg po bid or tid for weight gain in children. Side effects and body mass index were determined at baseline and during amantadine treatment.
A mean weight gain of 10.5 kg (19.9% mean increase in body weight) occurred from baseline to the beginning of amantadine treatment. Amantadine trial length averaged 14.5 weeks (range 4-33 weeks). A planned comparison using repeated measures analysis of variance demonstrated strong support for a "slowing weight gain" mechanism (p = 0.001) for weight gain and body mass. Weight loss was strongly correlated with length of amantadine treatment (p = < 0.05). One child experienced orthostatic hypotension with concomitant stimulant medication. No other side effects or exacerbation of psychiatric symptoms was reported.
Amantadine appears to stabilize weight gain related to psychotropic medications. Decreased weight and body mass index may occur with continued amantadine usage. Controlled trials of amantadine in children and adolescents taking weight-gain-inducing psychotropics are warranted.
本研究旨在探讨金刚烷胺是否会减缓或逆转接受抗精神病药物和/或心境稳定剂治疗的儿童和青少年的显著体重增加，这些药物可能会促进体重增加。
8名9至16岁的男孩和1名女孩及其父母同意参与一项关于金刚烷胺治疗儿童体重增加的开放试验，口服金刚烷胺100毫克，每日两次或三次。在基线期和金刚烷胺治疗期间测定副作用和体重指数。
从基线期到金刚烷胺治疗开始，平均体重增加了10.5千克（平均体重增加19.9%）。金刚烷胺试验的平均时长为14.5周（范围为4至33周）。一项使用重复测量方差分析的计划比较有力地支持了体重增加和体重指数的“减缓体重增加”机制（p = 0.001）。体重减轻与金刚烷胺治疗时长密切相关（p = < 0.05）。一名儿童在同时使用兴奋剂药物时出现体位性低血压。未报告其他副作用或精神症状加重情况。
金刚烷胺似乎能稳定与精神药物相关的体重增加。持续使用金刚烷胺可能会使体重和体重指数下降。有必要对服用导致体重增加的精神药物的儿童和青少年进行金刚烷胺的对照试验。
