Prakken Berent, Kuis Wietse, van Eden Willem, Albani Salvatore
Department of Pediatric Immunology, University Medical Center Utrecht, University Hospital for Children and Youth, PO Box 85090, Utrecht 3508 AB, The Netherlands.
Curr Rheumatol Rep. 2002 Dec;4(6):466-73. doi: 10.1007/s11926-002-0052-7.
Juvenile idiopathic arthritis (JIA) is in a majority of the cases of self-limiting, and sometimes even a self-remitting, disease. A growing amount of data suggests that active T cell regulation determines, at least partly, the clinical outcome of JIA. In experimental models of arthritis, a group of highly conserved microbial proteins, heat shock proteins (hsps), can be used to effectively prevent and treat arthritis. This protection is mediated through the induction of cross-reactive T cell responses to self-hsps. In JIA, naturally occurring T cell immune responses to hsps are associated with disease remission in restricted oligoarticular JIA. Moreover, those responses are associated with the induction of T cells with a regulatory phenotype. Taken together, these data imply that immune modulation with hsps can be an effective way to restore natural occurring T cell responses, and, thus, treat JIA and rheumatoid arthritis.
青少年特发性关节炎（JIA）在大多数情况下是一种自限性疾病，甚至有时会自行缓解。越来越多的数据表明，活跃的T细胞调节至少部分决定了JIA的临床结局。在关节炎的实验模型中，一组高度保守的微生物蛋白，即热休克蛋白（hsps），可用于有效预防和治疗关节炎。这种保护作用是通过诱导对自身hsps的交叉反应性T细胞应答来介导的。在JIA中，对hsps的天然T细胞免疫应答与少关节型JIA的疾病缓解相关。此外，这些应答与具有调节表型的T细胞的诱导有关。综上所述，这些数据表明，用hsps进行免疫调节可能是恢复天然T细胞应答从而治疗JIA和类风湿性关节炎的有效方法。
