Penttinen Markus A, Liu Yi, Granfors Kaisa
Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, Turku FIN-20520, Finland.
Curr Rheumatol Rep. 2002 Dec;4(6):518-24. doi: 10.1007/s11926-002-0060-7.
Spondyloarthropathies consist of many inflammatory diseases that are closely associated with human leukocyte antigen (HLA)-B27. One of these diseases is reactive arthritis (ReA), which is a joint inflammation that occurs after infections that are caused by certain gram-negative bacteria. The importance of these infections as causative agents of ReA has been clearly established. It is not clear, however, whether these infections contribute to the development of other forms of spondyloarthropathies. The exact mechanism by which HLA-B27 influences disease susceptibility in spondyloarthropathies remains to be determined. The role of HLA-B27 as an antigen-presenting molecule is certainly important in the pathogenesis of these diseases; however, recent data indicate that this molecule may exhibit other functions unrelated to antigen presentation, which may be important in the pathogenesis of ReA. In this paper, the authors summarize the current knowledge of the role of infection in the spondyloarthropathies.
脊柱关节病由许多与人类白细胞抗原（HLA）-B27密切相关的炎性疾病组成。其中一种疾病是反应性关节炎（ReA），它是由某些革兰氏阴性菌引起的感染后发生的关节炎症。这些感染作为ReA的病原体的重要性已得到明确证实。然而，尚不清楚这些感染是否会导致其他形式的脊柱关节病的发展。HLA-B27影响脊柱关节病易感性的确切机制仍有待确定。HLA-B27作为一种抗原呈递分子的作用在这些疾病的发病机制中肯定很重要；然而，最近的数据表明，该分子可能表现出与抗原呈递无关的其他功能，这可能在ReA的发病机制中很重要。在本文中，作者总结了目前关于感染在脊柱关节病中作用的知识。
