小肠结肠炎耶尔森菌和肠炎沙门氏菌肠炎血清型对培养的滑膜成纤维细胞的感染：关于反应性关节炎发病机制的超微结构研究
Infection of synovial fibroblasts in culture by Yersinia enterocolitica and Salmonella enterica serovar Enteritidis: ultrastructural investigation with respect to the pathogenesis of reactive arthritis.
作者信息
Meyer-Bahlburg A, Brinkhoff J, Krenn V, Trebesius K, Heesemann J, Huppertz H I
机构信息
Children's Hospital, University of Würzburg, D-97080 Würzburg, Germany.
出版信息
Infect Immun. 2001 Dec;69(12):7915-21. doi: 10.1128/IAI.69.12.7915-7921.2001.
Abstract
Synovial fibroblasts were infected with Yersinia enterocolitica or Salmonella enterica serovar Enteritidis and analyzed by electron microscopy and fluorescence in situ hybridization. Intracellular bacterial replication was followed by degradation leading to "ghosts" possessing lipopolysaccharides but not DNA. However, single bacteria survived for more than 2 weeks. Therefore, transient intra-articular infection might be the missing link between initial intestinal infection and late synovial inflammation in the pathogenesis of reactive arthritis.
摘要
将滑膜成纤维细胞用小肠结肠炎耶尔森菌或肠炎沙门氏菌肠炎血清型感染，并通过电子显微镜和荧光原位杂交进行分析。细胞内细菌复制后会发生降解，导致产生含有脂多糖但不含DNA的“空壳”。然而，单个细菌存活超过了2周。因此，短暂的关节内感染可能是反应性关节炎发病机制中初始肠道感染与晚期滑膜炎之间缺失的环节。
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