Richman S P, Mavligit G M, Wolk R, Gutterman J U, Hersh E M
JAMA. 1975 Dec 22;234(12):1233-5. doi: 10.1001/jama.234.12.1233.
Because of the serious toxicity of intralesionally injected BCG, including high fever, local ulceration, chronic drainage, and disseminated BCG disease, 13 patients received local BCG immunotherapy by the new approach of epilesional scarification. Three patients had complete responses, four had partial responses, and six had no response. Toxic reactions were minimal compared to those reported for intralesionally given BCG.
由于病灶内注射卡介苗具有严重毒性，包括高热、局部溃疡、慢性引流以及播散性卡介苗病，13例患者采用新的癫痫病灶划痕法接受局部卡介苗免疫治疗。3例患者完全缓解，4例部分缓解，6例无反应。与报道的病灶内注射卡介苗相比，毒性反应极小。
