Edwards M J J, Hargreaves I P, Heales S J R, Jones S J, Ramachandran V, Bhatia K P, Sisodiya S
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK.
Neurology. 2002 Nov 12;59(9):1447-9. doi: 10.1212/wnl.59.9.1447.
Serum glutathione levels were assessed in a patient with genetically proven Unverricht-Lundborg disease (ULD) before and during treatment with the antioxidant N-acetylcysteine (NAC). Glutathione levels were low before treatment, and increased during treatment. This increase was mirrored by an improvement in seizures, but not in myoclonus or ataxia. Three other patients with clinically determined ULD showed a variable response and some notable side effects during treatment with NAC.
在一名经基因证实患有翁韦里希特-伦德堡病（ULD）的患者中，在使用抗氧化剂N-乙酰半胱氨酸（NAC）治疗前和治疗期间评估了血清谷胱甘肽水平。治疗前谷胱甘肽水平较低，治疗期间有所升高。这种升高与癫痫发作的改善相呼应，但肌阵挛或共济失调没有改善。另外三名临床诊断为ULD的患者在使用NAC治疗期间表现出不同的反应和一些明显的副作用。
