Egsgaard Line Lindhardt, Wang Li, Arendt-Nielsen Lars
Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Alborg, Denmark.
Exp Brain Res. 2009 Mar;193(3):361-9. doi: 10.1007/s00221-008-1632-1. Epub 2008 Nov 15.
The alpha rhythm (7.5-12 Hz) is one of the fundamental features of the human EEG which usually has maximum amplitude over occipital regions. It is well recognized that individuals have highly different magnitudes of alpha EEG. This study examined occipital alpha EEG activity during different levels of experimental tonic cuff-pressure pain. The aim was to study the pain reactions and pain-EEG relationship in subjects with high alpha (H(alpha)) and low alpha (L(alpha)) EEG. Tonic experimental cuff-pressure induced pain, and high density EEG (124 channels) were used. The pain-EEG responses for the high alpha (above 600 microV(2) in total alpha power at baseline), and low alpha (below 600 microV(2) in alpha power at baseline) subjects were analyzed. Forty healthy volunteers were included and received tonic pain for 3 min at three intensities (VRS2) intense, but no pain, (VRS4) slight pain, and (VRS6) moderate pain. There were no differences in stimulus intensities to reach the three ratings between the H(alpha) and the L(alpha) groups. The H(alpha) and L(alpha) groups are highly different in alpha1(PO3), alpha1(PO4), alpha1(PO7) and alpha1(PO8) EEG powers. A positive correlation (P = 0.008) between alpha2(PO3) EEG and average subjective pain ratings was specific for the L(alpha) group. The H(alpha) group showed alpha1 desynchronization as pain increased, but no significant correlation between alpha1 EEG powers and average subjective pain ratings. The differences between the L(alpha) and the H(alpha) in alpha EEG powers and the different pain-EEG responses may be related to different degrees of attention, fear of pain and pain related coping strategies.
α波（7.5 - 12赫兹）是人类脑电图的基本特征之一，通常在枕叶区域具有最大振幅。人们普遍认识到个体的α脑电幅度差异很大。本研究考察了不同水平的实验性张力性袖带压力疼痛期间的枕叶α脑电活动。目的是研究高α（H(α)）和低α（L(α)）脑电图受试者的疼痛反应及疼痛 - 脑电图关系。使用张力性实验性袖带压力诱导疼痛，并采用高密度脑电图（124通道）。分析了高α（基线时总α功率高于600微伏²）和低α（基线时α功率低于600微伏²）受试者的疼痛 - 脑电图反应。纳入40名健康志愿者，以三种强度（VRS2）剧痛但无痛觉、（VRS4）轻度疼痛和（VRS6）中度疼痛接受3分钟的张力性疼痛刺激。H(α)组和L(α)组达到三种疼痛评级的刺激强度没有差异。H(α)组和L(α)组在α1(PO3)、α1(PO4)、α1(PO7)和α1(PO8)脑电功率方面差异很大。α2(PO3)脑电图与平均主观疼痛评分之间的正相关（P = 0.008）是L(α)组特有的。H(α)组随着疼痛增加显示α1去同步化，但α1脑电功率与平均主观疼痛评分之间无显著相关性。L(α)组和H(α)组在α脑电功率上的差异以及不同的疼痛 - 脑电图反应可能与不同程度的注意力、对疼痛的恐惧以及与疼痛相关的应对策略有关。
