Rozanova G N, Voevodin D A, Stenina M A, Kushnareva M V
Russian State Medical University.
Bull Exp Biol Med. 2002 Feb;133(2):164-6. doi: 10.1023/a:1015503006854.
A relationship between enteric microbiocenosis and severity of type 1 diabetes mellitus was detected. Microbiological analysis showed II-IV degree dysbacteriosis in all diabetic children. Long-term therapy with probiotics aimed at eradication of opportunistic microflora resulted in recovery of microbiocenosis, which was paralleled by improvement of the clinical status, regression of complications in children who were ill for a long time, and prevention of complications in children with newly detected diabetes. These results indicate the leading role of chronic enteric toxic infectious process in the development of complications of type 1 diabetes. The significance of infection in the pathogenesis of other noninfectious diseases in man is discussed.
已检测到肠道微生物群落与1型糖尿病严重程度之间的关系。微生物学分析显示，所有糖尿病儿童均存在II-IV度菌群失调。旨在根除机会性微生物群的益生菌长期治疗导致微生物群落恢复，与此同时，临床状况改善，长期患病儿童的并发症消退，新诊断糖尿病儿童的并发症得到预防。这些结果表明慢性肠道毒性感染过程在1型糖尿病并发症发生发展中起主导作用。本文还讨论了感染在人类其他非传染性疾病发病机制中的意义。
