Kotulska-Wolwender Katarzyna, Larysz-Brysz Magdalena, Fus Zbigniew, Korczyńska Izabela, Górka Dariusz, Lewin-Kowalik Joanna
Katedry i Kliniki Neurologii, Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 2002;55(7-8):463-71.
Extracellular matrix turnover disturbances are implicated in many human diseases. Matrix Metalloproteinases (MMP) are believed to play a pivotal role in maintaining the intricate balance between extracellular matrix synthesis and degradation. These enzymes are active in the cleavage of many matrix proteins. There is evidence that matrix metalloproteinases activity changes in many pathological conditions, including inflammatory and degenerative disorders as well as tumour progression and metastases. This review focuses on the recent view on physiological and pathological function of MMPs. Authors aimed also to show the putative role of matrix metalloproteinases as a diagnostic tool in future medicine.
细胞外基质周转紊乱与许多人类疾病有关。基质金属蛋白酶（MMP）被认为在维持细胞外基质合成与降解之间的复杂平衡中起关键作用。这些酶在许多基质蛋白的裂解中具有活性。有证据表明，在许多病理状况下，包括炎症性和退行性疾病以及肿瘤进展和转移，基质金属蛋白酶的活性会发生变化。本综述重点关注基质金属蛋白酶生理和病理功能的最新观点。作者还旨在展示基质金属蛋白酶作为未来医学诊断工具的潜在作用。
