Wilson Annette, Pitt Bruce, Li Song
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15213, USA.
Biosci Rep. 2002 Apr;22(2):309-22. doi: 10.1023/a:1020146924504.
Unmethylated CpG in bacterial DNA has recently been recognized as a danger signal to the mammalian immune system. This CpG signal can be greatly amplified when DNA is delivered via a lipidic vector. The CpG effects are affected by the administration route, and can be either beneficial or harmful. In this review, we will summarize our current understanding about the mechanism of action of the immunostimulatory motifs. Emphasis will be placed on the discussion of the complicated roles of CpG when CpG DNA or oligonucleotides are administered in vivo using liposomes as a delivery vehicle.
细菌DNA中的未甲基化CpG最近被认为是哺乳动物免疫系统的危险信号。当通过脂质载体递送DNA时，这种CpG信号可被大大放大。CpG效应受给药途径影响，可能有益也可能有害。在本综述中，我们将总结目前对免疫刺激基序作用机制的理解。重点将放在讨论当使用脂质体作为递送载体在体内施用CpG DNA或寡核苷酸时CpG的复杂作用。
