CpG DNA作为黏膜免疫的强效诱导剂：对黏膜感染免疫预防和免疫治疗的意义。
CpG DNA as a potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal infections.
作者信息
Harandi Ali M, Holmgren Jan
机构信息
Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute (GUVAX), Göteborg University, Medicinaregatan 7A, 40530 Göteborg, Sweden.
出版信息
Curr Opin Investig Drugs. 2004 Feb;5(2):141-5.
PMID:15043387
Abstract
Recent advances in immunology reveal that vertebrate innate immune systems use pattern-recognition receptors, of which the best characterized is the toll-like receptor (TLR) family, to specifically detect pathogen-associated molecular patterns (PAMPs) present in infectious agents. Based on this, use of synthetic PAMPs has attracted much interest for specific immunoprophylaxis and immunotherapy purposes. Among the PAMPs, immunostimulatory CpG DNA, a TLR9 ligand, displays promising potent immunostimulatory and adjuvanticity in different settings. In this review, recent developments in the use of CpG DNA for inducing immunity in the mucosal tissues will be highlighted.
摘要
免疫学的最新进展表明，脊椎动物的先天免疫系统利用模式识别受体来特异性检测感染因子中存在的病原体相关分子模式（PAMP），其中研究最充分的是Toll样受体（TLR）家族。基于此，合成PAMP的应用因其特定的免疫预防和免疫治疗目的而备受关注。在这些PAMP中，免疫刺激性CpG DNA是一种TLR9配体，在不同情况下显示出有前景的强大免疫刺激和佐剂活性。在这篇综述中，将重点介绍使用CpG DNA在黏膜组织中诱导免疫的最新进展。
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