Kanaly Kym A, Berman Jennifer R
Department of Urology, Female Sexual Medicine Center at UCLA, 924 Westwood Blvd., Suite 515, Los Angeles, CA 90024, USA.
Curr Womens Health Rep. 2002 Dec;2(6):409-16.
Depression often coexists with sexual dysfunction, and the medical treatment of depression can further worsen sexual symptoms or cause de novo sexual dysfunction in a person who did not experience it prior to treatment. There are many drugs that can adversely affect sexual response. Among antidepressants, this effect is commonly observed with selective serotonin-reuptake inhibitors (SSRI). Various strategies for the treatment of SSRI-related sexual dysfunction have been studied, including: awaiting spontaneous remission of sexual dysfunction; reducing the dose of medication; taking a "drug holiday"; adding another drug to help reverse sexual symptoms; changing antidepressants; or initially starting with a different antidepressant that is known to have fewer or no sexual side effects. Overall, it is important to address sexual health when caring for a patient--to improve drug compliance and the patient's well being.
抑郁症常与性功能障碍并存，而抑郁症的药物治疗可能会使性功能症状进一步恶化，或在治疗前未出现性功能障碍的患者中引发原发性性功能障碍。有许多药物会对性反应产生不利影响。在抗抑郁药中，选择性5-羟色胺再摄取抑制剂（SSRI）通常会出现这种效应。针对与SSRI相关的性功能障碍的各种治疗策略已得到研究，包括：等待性功能障碍自然缓解；减少药物剂量；停药一段时间；加用另一种药物以帮助逆转性功能症状；更换抗抑郁药；或最初选用已知有较少或无性功能副作用的不同抗抑郁药。总体而言，在护理患者时关注性健康很重要，这有助于提高药物依从性和患者的幸福感。
