血清素与女性性行为的药理学
Pharmacology of serotonin and female sexual behavior.
作者信息
Uphouse Lynda
机构信息
Department of Biology, Texas Woman's University, Denton, TX 76204, United States.
出版信息
Pharmacol Biochem Behav. 2014 Jun;121:31-42. doi: 10.1016/j.pbb.2013.11.008. Epub 2013 Nov 15.
Abstract
In this review, first a historical perspective of serotonin's (5-HT) involvement in female sexual behavior is presented. Then an overview of studies implicating 5-HT is presented. The effect of drugs that increase or decrease CNS levels of 5-HT is reviewed. Evidence is presented that drugs which increase 5-HT have negative effects on female sexual behavior while a decrease in 5-HT is associated with facilitation of sexual behavior. Studies with compounds that act on 5-HT₁, 5-HT₂ or 5-HT₃ receptors are discussed. Most evidence indicates that 5-HT₁A receptor agonists inhibit sexual behavior while 5-HT₂ or 5-HT₃ receptors may exert a positive influence. There is substantial evidence to support a role for 5-HT in the modulation of female consummatory sexual behavior, but studies on the role of 5-HT in other elements of female sexual behavior (e.g. desire, motivation, sexual appetite) are few. Future studies should be directed at determining if these additional components of female sexual behavior are also modulated by 5-HT.
摘要
在本综述中，首先介绍了血清素（5-羟色胺，5-HT）参与女性性行为的历史观点。然后概述了涉及5-HT的研究。回顾了增加或降低中枢神经系统5-HT水平的药物的作用。有证据表明，增加5-HT的药物对女性性行为有负面影响，而5-HT水平降低与性行为促进有关。讨论了作用于5-HT₁、5-HT₂或5-HT₃受体的化合物的研究。大多数证据表明，5-HT₁A受体激动剂会抑制性行为，而5-HT₂或5-HT₃受体可能发挥积极影响。有大量证据支持5-HT在调节女性性行为中的作用，但关于5-HT在女性性行为其他方面（如欲望、动机、性食欲）作用的研究很少。未来的研究应致力于确定女性性行为的这些其他组成部分是否也受5-HT调节。
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