Villain Max A, Pageaux Georges P, Veyrac Michel, Arnaud Bernard, Harris Alon, Greenfield David S
Service d'Ophtalmologie, Hôpital Gui de Chauliac, Centre Hospitalo-Universitaire de Montpellier, Montpellier, France.
Am J Ophthalmol. 2002 Nov;134(5):778-80. doi: 10.1016/s0002-9394(02)01650-1.
To describe the hemodynamic effect of oral acetazolamide administration on ocular perfusion in a patient with pseudotumor cerebri associated with Crohn disease.
Interventional case report.
A 20-year-old woman with a 5-year history of Crohn disease presented with a 2-week history of headache and blurred vision in both eyes. Ophthalmologic examination was normal. Fluorescein angiography showed a profound delay in retinal and choroidal perfusion. Lumbar puncture showed an opening pressure of 320 mm water. Therapy was initiated with oral acetazolamide 750 mg per day.
A subjective improvement of symptoms was noted over 4 days. Repeat fluorescein angiography showed resolution of the ocular perfusion deficit. No recurrent symptoms were noted 19 months after cessation of therapy.
Crohn disease may present with pseudotumor cerebri and severe ocular perfusion deficits that are reversible with oral acetazolamide therapy.
描述口服乙酰唑胺对一名患有与克罗恩病相关的假性脑瘤患者眼部灌注的血流动力学影响。
介入性病例报告。
一名患有5年克罗恩病病史的20岁女性，出现头痛和双眼视力模糊2周病史。眼科检查正常。荧光素血管造影显示视网膜和脉络膜灌注明显延迟。腰椎穿刺显示初压为320毫米水柱。开始每日口服750毫克乙酰唑胺进行治疗。
4天内症状有主观改善。重复荧光素血管造影显示眼部灌注不足得到解决。治疗停止19个月后未出现复发症状。
克罗恩病可能伴有假性脑瘤和严重的眼部灌注不足，口服乙酰唑胺治疗可使其逆转。
