Jeng Michael R, Rieman Martha, Bhakta Manoo, Helton Kathleen, Wang Winfred C
Department of Hematology-Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA.
J Pediatr Hematol Oncol. 2002 Dec;24(9):765-8. doi: 10.1097/00043426-200212000-00018.
A 13-year-old boy and a 16-year-old girl both presented with headaches and nausea after they were diagnosed with severe acquired aplastic anemia. Both patients had symptoms and signs consistent with the clinical syndrome of pseudotumor cerebri including headaches, nausea, papilledema, and elevated intracranial pressure. Both patients were treated with therapeutic lumbar puncture and acetazolamide, which relieved their symptoms. Acetazolamide dosage was given while the patients underwent an immunosuppressive regimen. We hypothesize that the pseudotumor cerebri in these two pediatric patients was the result of an increased production of cerebrospinal fluid in response to anemia and that the removal of fluid and treatment with acetazolamide appear to be helpful in such cases.
一名13岁男孩和一名16岁女孩在被诊断为严重获得性再生障碍性贫血后均出现头痛和恶心症状。两名患者的症状和体征均与假性脑瘤临床综合征相符，包括头痛、恶心、视乳头水肿和颅内压升高。两名患者均接受了治疗性腰椎穿刺和乙酰唑胺治疗，症状得到缓解。在患者接受免疫抑制治疗方案期间给予了乙酰唑胺剂量。我们推测，这两名儿科患者的假性脑瘤是由于贫血导致脑脊液生成增加所致，而在这种情况下，抽取液体和使用乙酰唑胺治疗似乎是有帮助的。
