de la Fuente-Fernández Raúl, Phillips Anthony G, Zamburlini Mariangela, Sossi Vesna, Calne Donald B, Ruth Thomas J, Stoessl A Jon
Pacific Parkinson's Research Centre, Vancouver Hospital and Health Sciences Center, University of British Columbia, Purdy Pavilion, 2221 Westbrook Mall, Vancouver, BC, Canada V6T 2B5.
Behav Brain Res. 2002 Nov 15;136(2):359-63. doi: 10.1016/s0166-4328(02)00130-4.
Using the ability of [11C]raclopride to compete with dopamine for D(2)/D(3) receptors, we investigated by positron emission tomography the effect of placebo (saline) injection on dopamine release in the ventral striatum of patients with Parkinson's disease. We found evidence for placebo-induced dopamine release of similar magnitude to that reported in healthy volunteers after amphetamine administration. However, in contrast to the dorsal striatum, there were no differences in [11C]raclopride binding potential changes between patients who experienced the reward (those who reported placebo-induced clinical benefit) and those who did not. We conclude that the release of dopamine in the ventral striatum (nucleus accumbens) is related to the expectation of reward and not to the reward itself. These observations have potential implications for the treatment of drug addiction.
利用[11C]雷氯必利与多巴胺竞争D(2)/D(3)受体的能力，我们通过正电子发射断层扫描研究了安慰剂（生理盐水）注射对帕金森病患者腹侧纹状体中多巴胺释放的影响。我们发现有证据表明，安慰剂诱导的多巴胺释放量与健康志愿者服用苯丙胺后报告的释放量相似。然而，与背侧纹状体不同，在体验到奖励的患者（那些报告有安慰剂诱导的临床益处的患者）和未体验到奖励的患者之间，[11C]雷氯必利结合潜力变化没有差异。我们得出结论，腹侧纹状体（伏隔核）中多巴胺的释放与奖励预期有关，而与奖励本身无关。这些观察结果对药物成瘾的治疗具有潜在意义。
